Publication Highlights

Research Field 3

Secondary structure of end group functionalized oligomeric-l-lysines: investigations of solvent and structure dependent helicity.

Canalp, M., et al. RCS Advances2019,9 (38), 21707-21714,DOI: http://dx.doi.org/10.1039/C9RA03099A.

Narrow-dispersed, end group-telechelic, oligomeric-(l-lysine(carboxybenzyl (Z)/trifluoroacetyl (TFA)))ns (n = 3–33) were prepared as a model system for studying assembly and secondary structure formation. Fibril formation of oligomeric-(L-lysine(Z/TFA))ns with shorter chain lengths (n = 7 and n = 3) were chosen to investigate the effect of the number of repeating units’ role on the self-assembly of the oligomers in TFE. Reproduced by permission of The Royal Society of Chemistry.

Induction of Chirality in β-Turn Mimetic Polymer Conjugates via Postpolymerization “Click” Coupling.

Deike, S., et al. Macromolecules 2017,50 (7), 2637-2644,DOI: http://dx.doi.org/10.1021/acs.macromol.7b00343.

Chiral and achiral β-turn mimetic polymer conjugates were synthesized, based on chiral helical poly(n-hexyl isocyanate)s (PHICs), and allowing to tune the distance between the PHIC-helix and the chiral center from 7 to 14 Å.. Circular dichroism (CD) spectra confirmed chirality induction from the chiral β-turn mimetic structure to the polymer backbone of the achiral PHIC over five chemical bonds via postpolymerization modification, and revealed a distance-dependent effect for the transmission of stereochemical information. Reproduced with permission. Copyright 2017©, American Chemical Society.