Research Field V

Drug-Delivery, Bio-Imaging and 3D-printing of materials

Reproduced with permission from the reference2. Copyright 2019©, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The development on novel materials is directed to on novel battery-electrodes, drug-release systems, stress-sensing-1 and (bio)-degradable soft/hard interfaces. Three dimensional (3D)-printing technology has become societies leading method to form materials for many applications. Prominent examples are the 3D- printing of self-healing polymer systems, pharmaceutical delivery materials and capsule-based multicomponent materials. Printing biodegradable polymers, capsules and materials for triggered time-release with defined long term delivery profiles represents an important challenge, currently addressed by proper design and synthesis of 3D-printable (co)-polyesters. We use multimode 3D-printing methods to prepare modern materials, with embedded self-healing-, mechanochromic- and pharmaceutical function.2

Reproduced with permission from the reference3. Copyright 2015©, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Delivery of pharmaceutical cargo as nanosized particles, vesicles or aggregates has become a prominent and medical useful endeavor.3-4 Polymers and lipids, equipped with modern STEALTH-technology are particularly interesting in this context, termed vesicles or polymersomes.5-13 Especially in view of site-specific delivery and imaging technology small, STEALTH-like particles with embedded functionalities are important, mediating both, biocompatibility and delivery of drugs, dyes and recognition sites. Based on our longstanding experience on artificial and biological membranes,3-4, 9, 14 we are currently developing ultra-small nanoparticles for high resolution imaging technology. Polymeric carrier-molecules consisting of a single chain are used in photoacoustic spectroscopy, displaying prolonged circulation times and excellent imaging properties.

References

  1. Döhler, D., et al., Qualitative sensing of mechanical damage by a fluorogenic „click“ reaction. Chemical Communications 2016, 52 (74), 11076-11079,DOI:http://dx.doi.org/10.1039/C6CC05390D.
  2. Rupp, H., et al., 3D Printing of Supramolecular Polymers: Impact of Nanoparticles and Phase Separation on Printability. Macromolecular Rapid Communications 2019, 1900467,DOI:https://doi.org/10.1002/marc.201900467.
  3. Schulz, M., et al., Mixed Hybrid Lipid/Polymer Vesicles as a Novel Membrane Platform. Macromolecular Rapid Communications 2015, 36 (23), 2031-2041,DOI:http://dx.doi.org/10.1002/marc.201500344.
  4. Binder, W. H., et al., Domains and Rafts in Lipid Membranes. Angewandte Chemie International Edition 2003, 42 (47), 5802-5827,DOI:http://dx.doi.org/10.1002/anie.200300586.
  5. Fuchs, C., et al., Molecular arrangement of symmetric and non-symmetric triblock copolymers of poly(ethylene oxide) and poly(isobutylene) at the air/water interface. Journal of Colloid and Interface Science 2015, 437 (0), 80-89,DOI:http://dx.doi.org/10.1016/j.jcis.2014.09.050.
  6. Schulz, M., et al., Lateral surface engineering of hybrid lipid-BCP vesicles and selective nanoparticle embedding. Soft Matter 2014, 10 (6), 831-839,DOI:http://dx.doi.org/10.1039/C3SM52040D.
  7. Olubummo, A., et al., Phase Changes in Mixed Lipid/Polymer Membranes by Multivalent Nanoparticle Recognition. Langmuir 2014, 30 (1), 259-267,DOI:http://dx.doi.org/10.1021/la403763v.