Research Field V

Drug-Delivery, Bio-Imaging and 3D-printing of materials

Reproduced with permission from the reference2. Copyright 2019©, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The development on novel materials is directed to on novel battery-electrodes, drug-release systems, stress-sensing-1 and (bio)-degradable soft/hard interfaces. Three dimensional (3D)-printing technology has become societies leading method to form materials for many applications. Prominent examples are the 3D- printing of self-healing polymer systems, pharmaceutical delivery materials and capsule-based multicomponent materials. Printing biodegradable polymers, capsules and materials for triggered time-release with defined long term delivery profiles represents an important challenge, currently addressed by proper design and synthesis of 3D-printable (co)-polyesters. We use multimode 3D-printing methods to prepare modern materials, with embedded self-healing-, mechanochromic- and pharmaceutical function2. 3D-printing enables to print drug-delivery systems, electrolytes and multifunctional materials with stress-diagnostic and self-healing properties.3-9

Reproduced with permission from the reference10. Copyright 2015©, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Delivery of pharmaceutical cargo as nanosized particles, vesicles or aggregates has become a prominent and medical useful endeavor.10, 11 Polymers and lipids, equipped with modern STEALTH-technology are particularly interesting in this context, termed vesicles or polymersomes.12-15 Especially in view of site-specific delivery and imaging technology small, STEALTH-like particles with embedded functionalities are important, mediating both, biocompatibility and delivery of drugs, dyes and recognition sites. Based on our longstanding experience on artificial and biological membranes,10, 11, 14, 16 we are currently developing ultra-small nanoparticles for high resolution imaging technology. Polymeric carrier-molecules consisting of a single chain are used in photoacoustic spectroscopy, displaying prolonged circulation times and excellent imaging properties.110

Publication Highlights V

References

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