Thio-Bromo “Click” Reaction Derived Polymer–Peptide Conjugates for Their Self-Assembled Fibrillar Nanostructures.

Kumar, S., et al. Macromolecular Bioscience 2020,2000048,DOI: https://doi.org/10.1002/mabi.202000048.

The synthesis and self-assembly of peptide-polymer conjugates into fibrillar nanostructures are reported, based on the amyloidogenic peptide KLVFF. A strategy for rational synthesis of polymer?peptide conjugates is documented via tethering of the amyloidogenic peptide segment LVFF (Aβ_17-20) and its modified derivative FFFF to the hydrophilic poly(ethylene glycol) monomethyl ether (mPEG) polymer via thio-bromo based “click” chemistry. The peptide-guided self-assembling behavior of the amphiphilic supramolecular materials is investigated exhibiting fibrillar nanostructure formation in binary aqueous solution mixture. Reproduced with permission. Copyright 2020©, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.