Kategorien
10. Juni 2020

Synthesis and Aggregation of Polymer-Amyloid β Conjugates.

Evgrafova, Z., et al. Macromolecular Rapid Communications 2019, 1900378, DOI: https://doi.org/10.1002/marc.201900378.

The synthesis of polymer-peptide conjugates composed of the amyloidogenic Alzheimer peptide, Aβ1-40, and poly(oligo(ethylene glycol)m acrylates) (m = 2,3) with different molecular weights (Mn = 1400-6600 g mol-1) is presented. Aggregation of these Aβ1-40 conjugates is accelerated upon attaching the polymer. Reproduced with permission. Copyright 2019©, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.