Canalp, M. B. et. al.; Macromolecular Chemistry and Physics, 2025, 2400510, 226, 11,https://doi.org/10.1002/macp.202400510
Advancing novel polymers for biomedical applications requires in-depth knowledge between their chemical structure and physical properties under conditions such as assembly or folding. Weh ave prepared hybrid-polymers containing lysine-residues (Lys) inside their main chain, separated by a stretch of n-alkyl-chains, (A-[Lysn = 1]m = 18) y ADMET polymerization of the bis-ω-ene-functional mono-L-lysine(Z)s (Lysn = 1). The hybrid-polymers, A-[Lysn = 1]m = 3, 7, 9, 18, 44 with molecular weights ranging from 1.3 to 17.6 kDa, display polydispersity (Đ) values in the range of 1.3–2.6. Comparison between these polymers and previously reported hybrid ADMET polymer proved the presence of α-helices and β-folds at elevated temperatures in the range of 20 to 200 °C. © 2025 The Author(s). Macromolecular Chemistry and Physics published by Wiley‐VCH GmbH. Open access