1. Juni 2020

Induction of Chirality in β-Turn Mimetic Polymer Conjugates via Postpolymerization “Click” Coupling.

Deike, S., et al. Macromolecules 2017,50 (7), 2637-2644,DOI: http://dx.doi.org/10.1021/acs.macromol.7b00343.

Chiral and achiral β-turn mimetic polymer conjugates were synthesized, based on chiral helical poly(n-hexyl isocyanate)s (PHICs), and allowing to tune the distance between the PHIC-helix and the chiral center from 7 to 14 Å.. Circular dichroism (CD) spectra confirmed chirality induction from the chiral β-turn mimetic structure to the polymer backbone of the achiral PHIC over five chemical bonds via postpolymerization modification, and revealed a distance-dependent effect for the transmission of stereochemical information. Reproduced with permission. Copyright 2017©, American Chemical Society.