7. Juni 2020

Hybrid polymers bearing oligo-l-lysine(carboxybenzyl)s: synthesis and investigations of secondary structure.

Canalp, M., et al. RSC Advances 2020,10 (3), 1287-1295,DOI: http://dx.doi.org/10.1039/C9RA09189K.

Hybrid polymers of peptides resembling (partially) folded protein structures are promising materials in biomedicine, especially in view of folding-interactions between different segments. In this study polymers bearing repetitive peptidic folding elements, composed of N-terminus functionalized bis-ω-ene-functional oligo-l-lysine(carboxybenzyl(Z))s (Lysn) with repeating units (n) of 3, 6, 12, 24 and 30 were successfully synthesized to study their secondary structure introduced by conformational interactions between their chains. We can demonstrate the influence of chain length of the generated polymers on the formation of secondary structures by comparing Lysnswith varying n values to the ADMET-polymers in a helicogenic solvent. Reproduced by permission of The Royal Society of Chemistry.