Hilgeroth, P. S. et. al., Macromol. Rapid. Commun., 2025, e00321, 47, 14, https://doi.org/10.1002/marc.202500321
Poly-iso-butylene (PIB) is a well known biocompatible polymer with application as a solid drug delivery system. We here investigate the impact of embedded oligo-alanine-units (Ala) to induce beta-sheets and the release of drugs from a so solidified PIB. Based on mono- (PIB-Ala2-Ac, 12,2 kDa) and bivalent PIB-polymers (PIB-(Ala2-Ac)2, 16,7 kDa) with attached oligo(alanines) as endgroups were synthesized and induce beta-sheets to adjust the mechanical strength of these biomaterials. Two drugs, nimodipine and triamcinolone acetonide, are incorporated into different PIB matrices and display a stable release of the drugs over a period of 42 days into a PBS buffer, thus presenting an attractive material for long-term targeted release with adjustable mechanical properties. © 2025 The Author(s). Macromolecular Rapid Communications published by Wiley‐VCH GmbH. Open access.