Wu, Y. et. al, Adv. Mater. 2025, 2502416, https://doi.org/10.1002/adma.202502416
We report a hydrogen-bonded (H-bonded) supramolecular nanoformulation generated by self-sorting of chemo-prodrug (FPtF) and phototherapeutics (BPeB) to reach an autonomous nanomedicine with improved anti-tumor efficacy by combining chemo/phototherapy (CT/PT). To directly stimulate phototherapy from BPeB via near-infrared (NIR) light, upconversion nanoparticles (UCNPs, β-NaYF4:Yb,Er) are encapsulated to form polymeric nanomicelles, i.e., F/B/U@PHDO, accompanied with a chemo-prodrug release through pH/thermal-stimuli. © 2025 Wiley-VCH GmbH